The health effects of BPA have been the subject of prolonged public and scientific debate. [70][71] The body first converts it into more water-soluble compounds via glucuronidation or sulfation, which are then removed from the body through the urine. It is not a plasticizer,[11] although it is often wrongly labelled as such. Excessive amounts of bisphenol A generate linear high molecular compounds with hydroxyl-, etherand epoxy-terminated groups. Polycarbonate plastic is a lightweight, high-performance plastic that possesses a unique balance of toughness, optical clarity, high heat resistance, and excellent electrical resistance. BPA is also found in epoxy resins, which act as a protective lining on the inside of some metal-based food and beverage cans. Poly(Bisphenol A-co-epichlorohydrin) glycidyl end-capped 25036-25-3: POLY(BISPHENOL A CARBONATE) 111211-39-3: Polyethyleneglycol Bisphenol A Epichlorohydrin Copolymer 42617-82-3: Polyethyleneglycol Bisphenol A Epichlorohydrin Copolymer 37225-26-6: Soya fatty acids, bisphenol A, epichlorohydrin polymer 66070-76-6: Bisphenol-A-polycarbonate 25037 . The chemical formula of Bisphenol A isC15H16O2. Based on the effects of metabolism, internal exposures to the active form of BPA following oral administration are predicted to be below 1% or less of the total BPA level administered. Sign in to download full-size image Plastic containers have recycle codes on the bottom. The .gov means its official.Federal government websites often end in .gov or .mil. NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. Order: 200 kg Qingdao Cemo Technology Develop Co., Ltd. Since that time, the FDA has continued to review additional studies as they became available, including those addressing possible low-dose effects. Chemical Identity. Scientific studies show that in humans BPA is quickly metabolized and eliminated from the body. 2011 Sep 15;255(3):261-70. e) Doerge DR, Twaddle NC, Vanlandingham M, Fisher JW. Demonstrated that oral BPA administration results in rapid metabolism of BPA to an inactive form. In July, 2012, FDA took this action in response to a food additive petition filed by the American Chemistry Council (ACC) [9]. Toxicol Lett. [92] It is primarily a river pollutant,[93] but has also been observed in the marine environment,[94] in soils,[95] and lower levels can also be detected in air. Dianin in 1891. What is the formula of phenol formaldehyde resin? The CDC NHANES data are considered representative of exposures in the United States. BISPHENOL A DIGLYCIDYL ETHER RESIN,25068-38-6 - Buyers Guide for Chemicals is a directory of chemicals, chemical suppliers and producers. One reason people may be concerned about BPA is because human exposure to BPA is widespread. Bisphenol A | C15H16O2 | CID 6623 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. In particular, infants are considered to be at greater risk,[83] leading to bans on the use of BPA in baby bottles and related products by the US,[84] Canada,[85] and EU[86] amongst others. Bisphenol A was first synthesized by A.P. The method is a modification of NIOSH P&CAM A resource for kids, parents, and teachers to find fun and educational materials related to health, science, and the environment Bisphenol A (BPA) is a chemical produced in large quantities for use primarily in the production of polycarbonate plastics. This search feature obtains best-matches with the terms you choose, and shows an overall score based on the scientific rankings. [34] These are not always removed and are known impurities in commercial samples of BPA. Bisphenol A is an organic synthetic compound used in formulating plastics and epoxy resin. [91], BPA has been detectable in the natural environment since the 1990s and is now widely distributed. Concerns about the health effects of BPA have led some manufacturers replacing it with other bisphenols, such as bisphenol S and bisphenol F. These are produced in a similar manner to BPA, by replacing acetone with other ketones, which undergo analogous condensation reactions. Polycarbonate plastic is used to make critical components of many medical devices and their housings. Distillation and vacuum distillation are used to remove toluene and unreacted epichlorohydrin, respectively. . Epoxy is the family of basic components or cured end products of epoxy resins.Epoxy resins, also known as polyepoxides, are a class of reactive prepolymers and polymers which contain epoxide groups. Properties form viscous liquid Quality Level 100 composition Epoxide equivalent weight, 172-176 2005 2022 American Chemistry Council, Inc. Brand Names: Not applicable . Bisphenol A can leach into food from the protective internal epoxy resin coatings of canned foods and from consumer products such as polycarbonate tableware, food storage containers, water bottles, and baby bottles. [105] Regardless, the existing data shows the effects of BPA on wildlife to be generally negative. For example, FDA has participated with Health Canada in encouraging industry efforts to refine their manufacturing methods for the production of infant formula can linings to minimize migration of BPA into the formula. Toxicol Sci. It is alcohol, ketone and ether soluble but presents low solubility in water and carbon tetrachloride. Find out about the exciting discoveries being made by NIEHS and NIEHS-supported researchers that are helping to improve health and save lives. As a result, FDA amended its food additive regulations to no longer provide for these uses of BPA. Polym Adv Technol 2009; 20: 194-208. . BPA can be found in a range of products, such as: plastic food storage containers, including: pitchers. These materials are much more common but their BPA content will be low. 133 Cecil Street, FDA will update its assessment of BPA and will take additional action if warranted. BPA Initiatives - The National Institute of Environmental Health Sciences (NIEHS) and National Toxicology Program (NTP) have developed an integrated, multipronged, consortium-based approach to optimize BPA-focused research investments to more effectively address data gaps and inform decision making. General description. Bisphenol A (BPA) is a chemical used to make polycarbonate plastic. [74] These interactions are all very weak, but exposure to BPA is effectively lifelong, leading to concern over possible cumulative effects. BPA is best known for its use in the manufacture of polycarbonate plastics and epoxy resins, particularly those found in water bottles, baby bottles, and other beverage and food containers. BPA is also found in epoxy resins, which act as a protective lining on the inside of some metal-based food and beverage cans. Physical State: Powder. Toxicol Lett. . Chemical Economics Handbook. BPA is regularly used to strengthen products for human health and safety. This compound is synthesized by the condensation of acetone with phenol. The molecular structure of bisphenol A epoxy resin contains aromatic rings and lateral hydroxyl groups, which is beneficial to improve adhesion; in addition, the aromatic ring structure also gives the resin higher rigidity, tensile strength and thermal stability; in general, The main characteristics of bisphenol A epoxy type include: fast light curing reaction rate, high hardness and tensile strength after curing, high gloss of the film layer, and excellent chemical corrosion resistance. BPA's largest single application is as a co-monomer in the production of polycarbonates, which accounts for 6570% of all BPA production. They are produced by the addition of - unsaturated carboxylic acids to epoxy resins. Food cans and other metal containers may be coated with epoxy resin linings made with BPA to help prevent direct food contact with metal, which helps protect food from contamination and spoilage. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. This group may lie within the body of the molecule but is usually terminal. Epoxy resins made with BPA are tough and readily adhere to metal surfaces, making them excellent materials for protective coatings. Strong, shatter-resistant polycarbonate is used for helmets and protective sports visors to help protectchildren and athletes from injuries. Bisphenol A- (epichlorhydrin)epoxy resin, polymer with polyethylene glycol, castor oil and triethylenetetramine IUPAC names 1 Print infocard Substance identity Substance identity The 'Substance identity' section is calculated from substance identification information from all ECHA databases. BPA seems to bind strongly to ERR- (dissociation constant = 5.5 nM), but only weakly to the ER. Some, but not all, plastics that are marked with recycle codes 3 or 7 may be made with BPA. Empirical Formula (Hill Notation): C21H24O4 CAS Number: 1675-54-3 Molecular Weight: 340.41 Beilstein: 299026 EC Number: 216-823-5 MDL number: MFCD00080480 PubChem Substance ID: 57654090 NACRES: NA.77 Pricing and availability is not currently available. NIEHS has a goal to ensure job opportunities and career enhancements programs for both our work force and our community. There is no scientific basis to say that BPA-free products are safer than products with BPA. Get info of suppliers, manufacturers, exporters, traders of Bisphenol Resin for buying in India. NIEHS intramural scientists have defined descriptive terms of particular relevance to their own research, and have ranked those terms accordingly. 2014 May;139(1):4-20. doi: 10.1093/toxsci/kfu021. As is the case when foods are in direct contact with any packaging material, small, measurable amounts of the packaging materials may migrate into food and can be consumed with it. . [90] BPA binding to ERR- preserves its basal constitutive activity. The degree to which BPA leaches from polycarbonate bottles into liquid may depend more on the temperature of the liquid or bottle, than the age of the container. Add bisphenol A and epichlorohydrin in the amount of 1:4 into a three-necked flask equipped with a reflux device, place it in a constant-temperature oil bath, melt it with 70 C of heat, and dropwise 28.57% aqueous sodium hydroxide solution with a dropping funnel, in which the ratio of the amount of sodium hydroxide and bisphenol A is 4:1. An amendment of the food additive regulations based on abandonment is not based on safety, but is based on the fact that the regulatory authorization is no longer necessary for the specific use of the food additive because that use has been permanently and completely abandoned. Its current uses are as a primary monomer in polycarbonate plastic and epoxy resins. Research studies pursued by FDAs National Center for Toxicological Research have [6]: Found evidence in rodent studies that the level of the active form of BPA passed from expectant mothers to their unborn offspring, following oral exposure, was so low it could not be measured. 1). The results of the independent evaluations were released in April 2010, as FDA made the CFSAN report and other relevant information available for public comment. When government scientists review studies to make a safety conclusion, they look at the weight of the evidence, meaning the information available from all sources, and how well each study was conducted. About 2530% of all BPA is used in the manufacture of epoxy resins and vinyl ester resins. (the chemical formula is shown in Fig. tions of epoxy resins can be preset by the chemical structure of the resin and hardener, as well as by the . With more than half of the global demand, the Asian market will . Structural formula Name CAS Reactants; Bisphenol AF: 1478-61-1: Phenol: Hexafluoroacetone: Bisphenol F: 620-92-8: Phenol: BPA is an important industrial chemical, which is mainly used as a raw material of polycarbonate and epoxy resin. bisphenol a epoxy resin price are designed to form other substances and play a crucial role in numerous important reactions. [25], In 1934, workers at I.G. The primary source of exposure to BPA for most people is through the diet. Bisphenol A was investigated in the 1930's during the search for synthetic estrogens. Polycarbonate plastic made with BPA is shatter-resistant, lightweight, and has high optical clarity similar to glass. Chemical name Common names and synonyms CAS number EC number Concentration; 4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane: a) Churchwell MI, Camacho L, Vanlandingham MM, Twaddle NC, Sepehr E, Delclos KB, Fisher JW, Doerge DR. Poly(Bisphenol-A-co-epichlorohydrin) (PBE) is an epoxy based resin that is a phenoxy polymer derived from bisphenol A and epichlorohydrin. 2010 Oct 30;24(20):3011-20. n) Yang X, Doerge DR, Fisher JW. 2013 Jul 1;270(1):45-59. Bisphenol A (BPA, 80-05-7) is an organic compound used predominantly in the production of products made of polycarbonate plastic and epoxy resins that line food and beverage cans. It is important to note that scientific experts at FDA, and other regulatory bodies, review the full weight of the scientific evidence when making decisions about safety. Toxicol Sci. In the fall of 2014, FDA experts from across the agency, specializing in toxicology, analytical chemistry, endocrinology, epidemiology, and other fields, completed a four-year review of more than 300 scientific studies. [98], In all cases, wastewater treatment can be highly effective at removing BPA, giving reductions of 9198%. The epoxide resins (also widely known as epoxy resins and, occasionally, as ethoxyline resins) are characterised by the possession of more than one 1,2-epoxy group (I) per molecule. Reports indicate that it is a minor skin irritant as well, although less so than phenol. Specialty Chemicals And Polymers. (2013) A new approach to synergize academic and guideline-compliant research: the CLARITY-BPA research program. NIEHS sponsors and co-sponsors scientific meetings, conferences, and events throughout the year. The condensation of acetone (hence the suffix 'A' in the name)[32] with two equivalents of phenol is catalyzed by a strong acid, such as concentrated hydrochloric acid, sulfuric acid, or a solid acid resin such as the sulfonic acid form of polystyrene sulfonate. In order to formulate an epoxy adhesive, one must have either bisphenol A or bisphenol F. Bisphenol A (BPA) is generally preferred for its curing properties. It is prepared by the reaction of two equivalents of phenol with one equivalent of acetone. These studies also addressed questions about how long it takes for the body to dispose of BPA. In recent years, many claims have been made about the health effects of BPA. It can also be used in the formation of solid polymeric electrolyte for potential application in electrochemical devices. read more. [27], In terms of the endocrine disruption controversy, the British biochemist Edward Charles Dodds tested BPA as an artificial estrogen in the early 1930s. These meetings are listed in the NIEHS Events Calendar and are open to the general public. [7] Thus, in bisphenol F, the F signifies formaldehyde. [17] Although BPA exposure is common it does not accumulate within the body, with toxicokinetic studies showing the biological half-life of BPA in adult humans to be around two hours. Many of these studies addressed how the body disposes of or metabolizes BPA. 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